RB1: a prototype tumor suppressor and an enigma

The retinoblastoma susceptibility gene (RB1) was the first tumor suppressor gene to be molecularly defined.RB1 mutations occur in almost all familial and sporadic forms of retinoblastoma, and this gene is mutated at variable frequencies in a variety of other human cancers. Because of its early discovery, the recessive nature of RB1 mutations, …

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Ginsenoside Rb1 Prevents Oxidative Stress-Induced Apoptosis

3.2. Ginsenoside Rb1 Reduced Intracellular ROS Level and Protects C2C12 Myoblasts against Apoptosis. We further detected the protein expression of γ-H2AX, a marker of DNA damage during oxidative damage.The increase in protein level of γ-H2AX was determined in H 2 O 2-treated cells and was blocked by Rb1 pretreatment (Figures …

RB1, development, and cancer

The pocket proteins. Rb1 is the founding member of a small gene family that also includes the Rbl1 (p107) and Rbl2 (p130) genes. Of these three family members, Rb1 is clearly the focus of attention because of its well documented function as a tumor suppressor gene. Despite the fact that they share partially overlapping functions, Rbl1 and Rbl2 are rarely …

RB1 Status in Triple Negative Breast Cancer Cells Dictates

Triple negative breast cancer (TNBC) includes basal-like and claudin-low subtypes for which only chemotherapy and radiation therapy are currently available. The retinoblastoma (RB1) tumor suppressor is frequently lost in human TNBC. Knockdown of RB1 in luminal BC cells was shown to affect response to endocrine, radiation and …

Frontiers | Spectrum of RB1 Germline Mutations and …

Retinoblastoma (Rb) is a primary intraocular malignant tumor that occurs primarily in children, and results from loss-of-function mutations in the RB transcriptional corepressor 1 (RB1) gene. Genetic testing forms the basis of genetic counseling for affected families, as well as for clinical management of this disease. The aim of this study was to identify …

Loss of Rb1 Enhances Glycolytic Metabolism in Kras-Driven …

2.1. Steady-State Metabolomics Highlights Metabolic Discrepancies in Rb1-Deficient Lung Tumors In Vivo. The loss of Rb1 accelerates lung tumor progression in mutant Kras-driven lung cancer in vivo, resulting in the development of higher grade adenocarcinomas and decreased overall survival [].Based on the emerging evidence that …

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Cells Lacking the RB1 Tumor Suppressor Gene Are …

Identifying therapeutic targets in SCLC has been challenging, partly because driver mutations in SCLC are primarily loss of function (LOF), typically involving the tumor suppressor genes RB1 and TP53 ().The importance of these two tumor suppressors in SCLC is underscored by genetically engineered mouse studies, where inactivation of …

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RESURGENCE BOOSTER [RB01] CARDLIST|Digimon Card …

RB1-035; R; Tamer; Hokuto Amanokawa. Form-Attribute-Type-DP - Play Cost 2 Digivolve Cost 1-Digivolve Cost 2-Effect [Start of Your Turn] If your opponent has 3 or more Tamers, gain 1 memory. [All Turns] When an opponent plays a Digimon, by suspending this Tamer, gain 1 memory if that Digimon is level 4 or higher, and <Draw 1> if it is level 3.

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RB1 protein expression summary

RB transcriptional corepressor 1. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. RB1 (OSRC, PPP1R130, RB) Protein classi. Assigned HPA protein class (es) for the encoded protein (s). Cancer-related genes. Disease related genes. Human disease related genes.